That so-called earthquake swarm gave authorities warning that an eruption was likely and allowed more than 5,000 people to be evacuated, avoiding casualties.
The new fissure opened after what the Canary Islands Volcanology Institute said was a 3.8-magnitude quake late Monday.
La Palma, with a population of some 85,000 people, is part of the volcanic Canary Islands.
Lava by Tuesday had covered 106 hectares (about 260 acres) of terrain and destroyed 166 houses and other buildings, according to the European Union’s Earth Observation Program, called Copernicus.
Unstoppable rivers of lava, as much as six meters (nearly 20 feet) high, rolled down hillsides, burning and crushing everything in their path.
The lava was expected it to reach the Atlantic Ocean on Tuesday, where it could cause explosions and produce clouds of toxic gas. Scientists monitoring the lava measured it at more than 1,000 C (more than 1,800 F).
Scientists say the lava flows could last for weeks or months.